Tuesday, November 13, 2012

Eupatorium perfoliatum Boneset

Eupatorium perfoliatum L.
Family: Compositae / Asteraceae
Synonyms: Cunigunda perfoliata, Eupatorium chapmanii, Eupatorium connatum, Eupatorium salviifolium, Eupatorium truncatum, Uncasia perfoliata, Uncasia truncata 

Common names: Agueweed, Boneset, Bonset, Common Boneset, Common Thoroughwort, Feverwort, Indian Sage, Thoroughwax, Thoroughwort
Deutsch: Durchwachsener Wasserdost
French: Eupatoire Perfoliée

Uses: Boneset is native to North America and has a long history of use among Native Americans, Eclectic physicians, and physiomedicalists. It is a strong bitter that acts on the liver and gallbladder, and it has a strong diaphoretic action that gives it great utility in reducing fevers due to influenza.

Used in sweat baths as an emetic to eliminate cold and bile.[Florida ethnobotany]

Indications (Boneset) — Anorexia, Arthrosis, Backache, Bacteria, Biliousness, Bleeding, Bronchosis, Bruise, Cancer, Catarrh, Chill, Cold, Constipation, Cough, Cramp, Debility, Dengue, Dermatosis, Dropsy, Dysmenorrhea, Dyspepsia, Fever, Flu, Fracture, Gastrosis, Gonorrhea, Gout, Headache, Hematemesis, Hemorrhoid, Immunodepression, Indigestion, Infection, Inflammation, Insomnia, Malaria, Myalgia, Nephrosis, Osteosis, Pain, Pharyngosis, Pleurisy, Pneumonia, Rheumatism, Snakebite, Sore Throat, Stomachache, Tumor, Typhoid, Ulcer, Urethrosis, Virus, Water Retention. [Handbook of Medicinal Herbs]

Eupatorium perfoliatum is both a rich source of quercetin and a traditional treatment for flu. Quercetin may also play a role in tumor inhibition. [Medical Herbalism The Science And Practice Of Herbal Medicine]

Boneset (Eupatorium perfoliatum L.) also known as ague weed, thorough stem or thoroughwort, cross wort, and Indian sage. According to Reuter, boneset was "so called because the Indians use it as splints in binding a broken arm or leg," or the name may have resulted from the plant's use against breakbone fever or dengue. [Southern Folk Medicine 1750–1820 by Kay K. Moss]

Times of India News - Plant for Dengue   Dt. 13 Nov 2012

 The King Institute team headed by a Chennai-based homoeopath administered the drug extracted from Eupatorium perfoliatum to 50 patients with secondary dengue and found all of them recovered. “The platelet counts came under control for almost all patients and blood tests showed marked improvement,” said King Institute director Dr P Gunasekaran. The study, lead by Dr N R Jayakumar of Madan Homoeo Clinic, was presented at an international symposium on ‘Challenges and strategies in the prevention and management of viral infections’ at Central Learther Research Institute recently.

    Jayakumar said it wasn’t a new idea to administer the drug to patients with dengue. Earlier the drug was given to patients in Delhi and Sri Lanka during epidemics. In June, the drug was administered to dengue patients at the Madurai Government Rajaji Hospitals. “We wanted to scientifically prove the drug is efficient. The patients were given two doses a day. The platelet count of all the patients improved. The good thing about this drug is that it can also be given alongside allopathic medicines,” Dr Jayakumar said.

    “In allopathic medicine, there is no drug for this disease. The only treatment is IV fluids to replace body fluids. Most patients we chose for the study had platelet count less than 10,000. We prevented death and blood transfusion in all the 50 patients who took this drug,” said Dr Gunasekaran.

    Dengue virus is spread by aedes mosquito. The symptoms include fever, headache, body pain and rashes. Some patients develop life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage.


Published articles & Patents of Eupatorium perfoliatum
1.    Bioassay-guided fractionation of Eupatorium Perfoliatum L. towards anti-Influenza A-activity leads to dicaffeoyl quinic acids
Derksen, A.; Sendker, J.; Hafezi, W.; et al.
Conference: International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF Location: New York, NY Date: JUL 28-AUG 01, 2012  - PLANTA MEDICA  Volume: 78   Issue: 11   Pages: 1087-1087   Published: AUG 2012
2.    Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications
Hensel, Andreas; Maas, Mareike; Sendker, Jandirk; et al. - JOURNAL OF ETHNOPHARMACOLOGY  Volume: 138   Issue: 3   Pages: 641-651   DOI: http://dx.doi.org/10.1016/j.jep.2011.10.002   Published: DEC 8 2011
3.    Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines
Maas, Mareike; Deters, Alexandra M.; Hensel, Andreas - JOURNAL OF ETHNOPHARMACOLOGY  Volume: 137   Issue: 1   Pages: 371-381   DOI: http://dx.doi.org/10.1016/j.jep.2011.05.040   Published: SEP 1 2011
4.    An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum
Maas, Mareike; Hensel, Andreas; da Costa, Fernando Batista; et al. - PHYTOCHEMISTRY  Volume: 72   Issue: 7   Pages: 635-644   DOI: http://dx.doi.org/10.1016/j.phytochem.2011.01.025   Published: MAY 2011
5.    Eupatorium perfoliatum L.: Antiinflammatory and antiplasmodial activity of the dichloromethane extract and novel sesquiterpene lactones
Maas, M.; da Costa, F.; Deters, A.; et al.
Conference: 7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medical-Plant-and-Natural-Product-Research Location: Berlin, GERMANY Date: AUG 29-SEP 02, 2010  - PLANTA MEDICA  Volume: 76   Issue: 12   Pages: 1180-1180   Published: AUG 2010
6.    Homeopathic pharmaceutical composition used for treating dengue fever and preventing e.g. hemorrhagic complications, comprises Crotalus horridus, Eupatorium perfoliatum and phosphorus
Patent Number: WO2010071951-A1; BR200805555-A2
Patent Assignee: FARMACIA E LAB HOMEOPATICO ALMEIDA PRADO LTDA
7.    Capillary electrophoresis of phenolic compounds from Eupatorium perfoliatum L. (Asteraceae)
Lechtenberg, M.; Maas, M.; Quandt, B.; et al.
Conference: 55th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-
Research-and-Natural-Product-Research Location: Geneva, SWITZERLAND Date: AUG 16-20, 2009  - PLANTA MEDICA  Volume: 75   Issue: 9   Pages: 993-994   Published: JUL 2009
8.    Caffeic Acid Derivatives from Eupatorium perfoliatum L.
Maas, Mareike; Petereit, Frank; Hensel, Andreas - MOLECULES  Volume: 14   Issue: 1   Pages: 36-45   DOI: http://dx.doi.org/10.3390/molecules14010036   Published: JAN 2009
9.    Activity-guided isolation and identification of free radical-scavenging components from ethanolic extract of Boneset (leaves of Eupatorium perfoliatum)
Habtemariam, Solomon - NATURAL PRODUCT COMMUNICATIONS  Volume: 3   Issue: 8   Pages: 1317-1320   Published: 2008
10.    Effects of homeopathic medications Eupatorium perfoliatum and Arsenicum album on parasitemia of Plasmodium berghei-infected mice
Lira-Salazar, G.; Marines-Montiel, E.; Torres-Monzon, J.; et al. - HOMEOPATHY  Volume: 95   Issue: 4   Pages: 223-228   DOI: http://dx.doi.org/10.1016/j.homp.2006.06.003   Published: OCT 2006
11.    Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum)
Habtemariam, S; Macpherson, AM - PHYTOTHERAPY RESEARCH  Volume: 14   Issue: 7   Pages: 575-577   DOI: http://dx.doi.org/10.1002/1099-1573(200011)14:7<575:: wbr="wbr">AID-PTR652>3.0.CO;2-1   Published: NOV 2000
12.    Herbal composition for treating mastitis in cows and sheep|containing extracts of Aconitum napellus, Atropa belladonna, Eupatorium perfoliatum and Phytolacca decandra
Patent Number: ZA9808643-A
Patent Assignee: LOMBARD J J
13.    IMMUNOLOGICALLY ACTIVE POLYSACCHARIDES OF EUPATORIUM-CANNABINUM AND EUPATORIUM-PERFOLIATUM
VOLLMAR, A; SCHAFER, W; WAGNER, H - PHYTOCHEMISTRY  Volume: 25   Issue: 2   Pages: 377-381   DOI: http://dx.doi.org/10.1016/S0031-9422(00)85484-9   Published: 1986
14.    A CONTROLLED CLINICAL-TRIAL FOR TESTING THE EFFICACY OF THE HOMEOPATHIC DRUG EUPATORIUM PERFOLIATUM D2 IN THE TREATMENT OF COMMON COLD
GASSINGER, CA; WUNSTEL, G; NETTER, P - ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH  Volume: 31-1   Issue: 4   Pages: 732-736   Published: 1981
15.    SESQUITERPENE LACTONES OF EUPATORIUM-PERFOLIATUM
HERZ, W; KALYANARAMAN, PS; RAMAKRISHNAN, G; et al. - JOURNAL OF ORGANIC CHEMISTRY  Volume: 42   Issue: 13   Pages: 2264-2271   DOI: http://dx.doi.org/10.1021/jo00433a017   Published: 1977
16.    EUPATORIUM PERFOLIATUM - PLANT WITH A HISTORY
HALL, TB - MISSOURI MEDICINE  Volume: 71   Issue: 9   Pages: 527-528   Published: 1974
17.    STEROLS AND TRITERPENES FROM EUPATORIUM-PERFOLIATUM
DOMINGUE.XA; GONZALEZ.JA; PAULINOR.M - PHYTOCHEMISTRY  Volume: 13   Issue: 3   Pages: 673-674   DOI: http://dx.doi.org/10.1016/S0031-9422(00)91386-4   Published: 1974
18.    STUDIES OF BYRON BOG IN SOUTHWESTERN ONTARIO .38. INSECTS ASSOCIATED WITH FLOWERING BONESET, EUPATORIUM PERFOLIATUM L
JUDD, WW - PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF ONTARIO  Volume: 99   Issue: SEP   Pages: 65-&   Published: 1968
19.    Cell shape and cell volume relations in the pith of Eupatorium perfoliatum L
Marvin, JW - AMERICAN JOURNAL OF BOTANY  Volume: 31   Issue: 4   Pages: 208-218   DOI: http://dx.doi.org/10.2307/2437607   Published: APR 1944

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